RE1-silencing transcription factor (REST) and REST-interacting LIM domain protein (RILP) affect P19CL6 differentiation

The RE1 binding protein REST regulates oligodendrocyte differentiation.

The RE1-silencing transcription factor (REST) represses the expression of neuronal-specific genes in non-neuronal cells by recruiting histone deacetylases (HDACs) and other histone modifying and chromatin remodeling proteins to the DNA. REST regulation of the expression of neuronal genes is required for the orderly developmental transition from a neuroepithelial stem cell to a functional neuron...

REST ( RE 1 - silencing transcription factor )

Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death.

Resveratrol (3,5,4'-trihydroxystilbene) (RSV), a polyphenol widely present in plants, exerts a neuroprotective function in several neurological conditions; it is an activator of class III histone deacetylase sirtuin1 (SIRT1), a crucial regulator in the pathophysiology of neurodegenerative diseases. By contrast, the RE1-silencing transcription factor (REST) is involved in the neurotoxic effects ...

Rest Interacts with Cbx Proteins and Regulates Polycomb Repressive Complex 1 Occupancy at 1 Re1 Elements 2 3 Transcription Regulatory Protein Interactions 16 Repressor Element 1 Silencing Transcription Factor / Neuron Restrictive Silencing Factor 17

Polycomb Repressive Complex 1 18 Bimolecular fluorescence complementation analysis of interactions in living cells 19 Chromatin immunoprecipitation analysis of regulatory element binding 20 Embryonic stem cell differentiation into neuronal progenitor cells 21 Integration of epigenetic and DNA sequence-dependent transcription regulation 22 2 23 Polycomb group (PcG) proteins control epigenetic in...

Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes.

The completion of whole genome sequencing projects has provided the genetic instructions of life. However, whereas the identification of gene coding regions has progressed, the mapping of transcriptional regulatory motifs has moved more slowly. To understand how distinct expression profiles can be established and maintained, a greater understanding of these sequences and their trans-acting fact...